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Consistent with these transcriptomic changes, histological analysis showed a marked reduction in crown-like structures (CLS) in the eWAT of Gpr146 / mice, indicating reduced macrophage infiltration and attenuated adipose tissue inflammation (Fig

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Following GLP-1 RA discontinuation, the patient experienced an increase in appetite, regained 7 kg (weight 167 kg, 79.4 kg/m 2 ) and was also later diagnosed with type 2 diabetes

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