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This variation reflects differences in baseline metabolism, starting weight, and how quickly the body responds to GLP-1 receptor activation

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More commonly used medications in the treatment of Type 2 DM include: Biguanide Dipeptidyl peptidase 4 (DPP-4) inhibitors Glucagon-like peptide 1 (GLP-1) receptor agonists Dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists Sodium-glucose cotransporter 2 (SGLT2) inhibitors Sulfonylureas Thiazolidinediones (TZDs) Biguanide The first and most foundational medication in type 2 diabetes management is metformin , the only drug in the biguanide class