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All experimental findings consistently demonstrate that the therapeutic efficacy of MSCs for PH is regulated by three critical factors

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Since decreased Parasutterella relative abundance may accompany increased stress 80,81 , the increased Parasutterella relative abundance that occurred in this study following diet switch likely arose from the weight loss-mediated negative energy state

Secondary mitochondrial dysfunction Acquired dysfunction may develop from oxidative stress, inflammation, nutrient deficiency, medication toxicity, toxic exposure, aging, metabolic disease, infection, poor sleep, inactivity or chronic illness

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