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Peroxynitrite, formed from the reaction of superoxide and NO, is a major trigger of DOX-induced apoptosis and necrosis in cardiac cells
In addition, -syn and p--syn levels increased in the insoluble fraction of RIPA following hypoxic treatment for 7 days, suggesting that hypoxia promoted the phosphorylation of -syn and long-term hypoxia promoted -syn to form abnormal aggregates in the insoluble fraction (Fig
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However, this acute oxidative stress serves as a hormetic stimulus that triggers adaptive responses, including upregulation of endogenous antioxidant systems including glutathione synthesis
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