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Introduction The gastrointestinal (GI) system plays a central role in human health as the primary site for digestion and nutrient absorption, while also influencing immunity, endocrine signaling, and mental well-being through the gutbrain axis

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In the nucleus, HMGB1 can interact with DNA and histones to maintain chromosome structure and function, while, in the cytoplasm, HMGB1 can combine with Beclin 1 protein to promote autophagy

Stem cells may be totipotent (capable of producing all the cells in an organism), pluripotent (able to differentiate into cells of any of the three germ layers), multipotent (produce only cells of a closely related family) or unipotent (produce only one type of cell)

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