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The pathway from subcutaneous injection to systemic circulation is straightforward: interstitial diffusion capillary uptake venous return cardiac output arterial distribution

It could also be involved in maintaining gut barrier functioning, through the synthesis of microbial anti-inflammatory molecules, which regulate cell permeability, preserving tight junctions proteins, and protecting intestinal cells of the mucous layer [55]

Heart rate, respiratory rate, and SpO 2 (oxygen saturation as measured by pulse oximetry) were recorded every 10 min (min) until the end of the EEG recording and 120 min after administration with a Philips IntelliVue MP50 monitor