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In line with these observations, the treatment of the murine syngeneic PCa and bladder cancer models with the JHU-083 inhibitor led to the reprogramming of the tumor-associated macrophages (TAMs) from an immunosuppressive to inflammatory state and increased TAM proliferation and glycolysis [99]

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Typical protocol: Dose: 200-300 mcg subcutaneously Timing: At bedtime (aligns with natural HGH release during sleep) Frequency: Daily for 3-6 months Results timeline: 3-6 months to notice meaningful changes Ipamorelin Ipamorelin is a growth hormone-releasing peptide (GHRP) that also stimulates pituitary HGH production but through a different receptor pathway than Sermorelin