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Patients with complex medical histories, multiple medications, or unclear contraindications may benefit from discussing semaglutide initiation with their primary care provider first

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Purifying long peptides is difficult, plus these GLP-1 peptide drugs have been modified to include a fatty acid side chain, and lipids themselves can be very difficult to purify, because theyre very hydrophobic, and tend to stick to the [purification] column, says Levine

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