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Ozempic approved in 2018 for type 2 diabetes

PLoS ONE 9(6):e101005 De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M et al (2010) GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis

GLP-1s remain life-changing even life-saving for millions of people

This has not been studied systematically, but the pharmacological principle of dose-response suggests that higher doses may produce more pronounced neurochemical effects, including effects on the reward system

Engage in regular exercise (both cardiovascular and resistance training)