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In these cases, provider evaluation must address whether baseline thyroid function is stable, TSH is well-controlled, and whether introducing a GLP-1 agent poses any incremental autoimmune risk for that individual

Most symptoms are mild to moderate, transient, and resolve within 4-8 weeks as physiologic tolerance develops

R.et al

Variants in FTO (fat-mass and obesity-associated), GLP1R (the GLP-1 receptor itself), MC4R (a satiety and energy-balance receptor), and TCF7L2 (a glucose-homeostasis transcription factor) describe the metabolic terrain a clinician is prescribing into