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Two copies (homozygous) cause a ~ 70% reduction in enzyme function

Not all peptides are created equal

Insulin resistance is characteristic of neurons in AD, and insulin has a beneficial effect on brain metabolism and bioenergetics

4.2.2 Systemic immunomodulation to counter neurodegenerative disease 4.2.2.1 Nanoparticle targeting of phagocytic pathways One strategy for neurodegeneration is to target microglial phagocytic pathways