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[99], which involved transplantations of fecal microbiota obtained from depressed patients into a microbiota-depleted antibiotic rat model, the animals developed depressive-like symptoms, which were manifested by behavioral differences such as decreased sucrose intake in the sucrose preference test, a lower number of entries to an open arm in the elevated plus-maze test, and an increase in a plasma kynurenine/tryptophan ratio

doi:10.1152/physrev.00034.2006

A pivotal study published in the New England Journal of Medicine reported that participants who received the highest dose of Zepbound (15 mg) lost an average of 22.5% of their body weight after 72 weeks of treatment