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Oxidative stress as a key feature of autoimmune thyroiditis: an update

To counteract the harmful effects of ROS, organisms have evolved a complex, three-line antioxidant defense system

A study on healthy controls described an inverse correlation between age (especially those older than 60 y/o), concomitantly low levels of circulating calcifediol and altered innate immune markers being the expression and function of various TLRs on immune cells, particularly those related to viral responses, and low levels of cathelicidin, which in turn were positively associated with calcifediol levels [186]