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At the highest doses, retatrutide seems to promise more significant weight loss than existing GLP-1s on the market but as dosage increases, so does the risk of side effects, mostly mild-to-moderate gastrointestinal issues, although one case of pancreatitis occurred in a patient on the 12mg dose during the phase II trial

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The approved product, available in multiple strengths, is bioequivalent to Xigduo XR and is indicated for the treatment of type 2 diabetes

BJU Int (2012) 110(7):9806

Healthcare professionals advocate for treatments with a solid foundation of clinical research, especially when it comes to interventions aimed at modifying the body