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Metformin Pathways: Pharmacokinetics and Pharmacodynamics

Weight-loss drug approved to treat sleep apnea in Canada Sleep apnea causes daytime sleepiness and is often tied to obesity Health Canada has approved weight-loss drug Zepbound for treating obstructive sleep apnea in adults with obesity

Key highlights: Once-daily oral administration No food or water restrictions No injections required ~12% mean weight loss in Phase 3 trials Improvements in cardiometabolic risk markers Indication: Approved for adults with obesity, or overweight individuals with weight-related comorbidities, alongside reduced-calorie diet and increased physical activity

Am J Physiol Endocrinol Metab (2017) 313(6):E651e62

& Beeson, C