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The NLRP3 inflammasome, closely related to CRC, is activated by TMAO-induced endothelial inflammation mediated by mitochondrial reactive oxygen species (ROS) (Yue et al., 2017)

Growth hormone receptor upregulation through the JAK2 pathway further drives fibroblast proliferation, reinforcing the preclinical case for BPC-157 for tendon and ligament recovery

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Cuadrado et al., 2020) and pharmacological activation of Nrf2 might also limit NF-B-mediated pulmonary inflammation caused by SARS-CoV-2 infection (Cuadrado et al., 2019, 2020

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