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Patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 micrograms per kg per day, accumulate aluminum at levels associated with central nervous system and bone toxicity

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Side Effects Side effects can vary, and both medications may include: Nausea Diarrhea Constipation Fatigue or GI discomfort Some users report that side effects diminish with continued use and gradual dose increases, which are common strategies in GLP-1 therapy

Much of the work described above has been generated by Bhm and colleagues, who also provided useful insights into the actions of these drugs using in vivo models of fibrosis ( Table 2 )

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