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These pathway-level predictions were experimentally validated, as PYC significantly suppressed IL-6 and IL-1 expression in lipopolysaccharide-induced BV2 microglial cells, supporting its multi-component, multi-target mode of action (Liu et al., 2024)

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J Biol Chem 279:4906449073 Muthaiyah B, Essa MM, Chauhan V, Brown WT, Wegiel J, Chauhan A (2009) Increased lipid peroxidation in cerebellum and temporal cortex of brain in autism

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