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However, the 7-day accumulation pattern means inconsistent dosing intervals may reduce steady-state stability and make it harder to distinguish between true lack of response and suboptimal pharmacokinetic timing

Tell your doctor about all your current medicines and any medicine you start or stop using

Retatrutide has a half-life of approximately 6 days, which supports once-weekly subcutaneous injection

If side effects are severe or persistent, the provider may adjust the dose, switch to a different GLP-1 agonist, or explore alternative treatments

Zepbound is approved for obesity with medically related conditions like obstructive sleep apnea