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In support to this theory, it has been demonstrated that GIP infusion increases the proliferation of neuronal progenitors in the dentate gyrus, while mice lacking GIP displayed deterioration in memorial tasks as a result of reduced neurogenesis [24]
GLP-1 medications act on receptors in the brain and gut to increase feelings of fullness, decrease cravings, slow stomach emptying, and improve blood sugar regulation
review papers summarise the design rationale without publishing the full sequence (PMID 39515565)
Despite the fact that the relationship between glucagon and body weight is well established, some research found no changes in food intake following glucagon administration, which suggests that appetite-independent mechanisms may play a role in the glucagon-mediated regulation of body weight [14]