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Histologic evidence from massive weight loss demonstrates increased elastic fiber density compared to morbidly obese skin, but altered collagen architecture and decreased dermal thickness are common, which can translate to visible laxity even if elastic fibers are on the rise

The dosage typically starts low and gradually increases to minimize side effects

That makes it different from medicines that act mainly through the GLP-1 pathway

While reducing 5% of baseline weight is conventionally regarded as clinically significant, a greater amount of weight loss influences different organs to varying extents

In 2021, a higher-dose version called Wegovy was approved for long-term weight management