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Key Takeaways: GLP-1 vs GIP Both are incretin hormones released by your intestines after eating GLP-1 primarily affects appetite, gastric emptying, and insulin secretion GIP influences insulin secretion, glucagon regulation, and fat metabolism Single GLP-1 agonists (semaglutide) produce 14.9% average weight loss Dual GLP-1/GIP agonists (tirzepatide) produce 22.5% average weight loss The dual action appears to create additive rather than merely overlapping effects Both receptor types play important roles in metabolic regulation Understanding the difference helps explain why tirzepatide shows superior results What Are Incretin Hormones

Patients who want to reduce or stop medication should work with a physician to create a structured plan rather than relying on willpower alone

J Neuroinflammation 16(1):242 Liu YY, Jiao ZY, Li W, Tian Q (2017) PI3K/AKT signaling pathway activation in a rat model of migraine

[1] [2] Because the drug is not yet licensed, all information regarding its side effects, including long-term risks, is derived from clinical trial data rather than post-marketing surveillance

Weekly injections tend to show faster and more consistent weight loss results compared to oral formulations because injectable medications bypass digestive breakdown and achieve higher bioavailability