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A Phase 2 clinical trial published in the New England Journal of Medicine in 2023 reported mean body weight reductions of approximately 24% at 48 weeks at the highest studied dose

The glucagon component can transiently raise blood glucose before the GLP-1 and GIP components bring it back down

Blood tests may show increased bilirubin, alkaline phosphatase, GGT, ALT, AST, or white blood cells when biliary obstruction or inflammation is present

Standard FDA review takes 10 to 12 months

Building upon this concept, and following the identification of hyperinsulinism as a specific metabolic hallmark in migraine patients [118], my research group developed and implemented a modified version of the Mediterranean diet tailored to individuals with insulin-related dysregulation