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Evidence grade Moderate (8/10) The GLP-1 semaglutide (#Ozempic) failed to improve mood and executive functioning in this, the first RCT of a GLP-1 for major #depression: sciencedirect.com/science/articl Weight loss was significant (all subjects were overweight/obese)

Medical case reports document approximately 100 instances of acute kidney injury associated with exenatide (Byetta), with most cases attributed to "pre-renal acute failure due to GLP-1-induced nausea and vomiting, decreased fluid intake, and significant loss of fluids"

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Peptide Interventions Peptide-based therapies are becoming powerful instruments in metabolic and reproductive optimization, providing localized means to control appetite, glucose metabolism, body composition, and reproductive hormone cues

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