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As a result, they usually resolve within a few days of the injection, and within a few weeks of longer-term use, says Fishman

GLP-1 agonists reduce insulin levels, and lower insulin triggers the kidneys to release stored sodium and water

Bariatric surgery is widely recognized as the most effective intervention for severe obesity, yielding significant and sustained weight loss in most patients

This reduction happens because hunger signals diminish and satiety arrives faster