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39,40 There may be a role for metformin as an adjuvant therapy in certain populations (eg, patients with comorbid T2DM), although further studies stratifying risk factors such as body mass index and age are needed

Research demonstrates that semaglutide users who maintain their dose, continue regular physical activity, and practice intentional eating patterns achieve weight reductions of 15 to 22 percent over 68 weeks

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Pregnant and breastfeeding women and those with chronic medical conditions or who are taking medication should consult their doctor or therapist before use

A recent study evaluated the GI safety profile of both semaglutide and tirzepatide, observing a notable increase in the incidence of GI issues with both drugs, with tirzepatide presenting a higher risk than semaglutide