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Barriers to these characterizations hinge on the nature of the R-domain, which is predicted to be unstructured based on low sequence conservation 19 and experimentally confirmed with circular dichroism 19,20 and proteolysis analysis that estimate as low as 5% helical content 20

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This pathway mainly regulates ferroptosis by inducing and activating the expression of SREBP1, which can target and activate the downstream SCD1, and SCD1 can inhibit cell ferroptosis by increasing the content of MUFA

Harris, A