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Compared to cytosolic NADK (cNADK), mitochondrial NADK (mNADK) has a distinctive feature that it can directly phosphorylate nicotinamide adenine dinucleotide (NADH) to generate NADPH to alleviate oxidative stress in mitochondria

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Centromeric inactivation during aging can lead to chromosome segregation defects, genomic instability and decreased cell proliferation, which has become an important driver of aging

However, the classical upstream molecules of NF-B, ERK1/2 and p38 MAPK (mitogen activated protein kinase), did not exhibit significant differences [52]

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