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Smith NK, Hackett TA, Galli A, Flynn CR (2019) GLP-1: molecular mechanisms and outcomes of a complex signaling system

At the time, we didnt fully understand how it reduced food intake, but it did

Instead of increasing GLP-1 activity, it blocks or reduces it

This is the same recommendation the American Heart Association makes for cardiovascular health, but it has direct benefits for gut motility too

While the breadth of GLP-1 medicines clinical impact is striking, the review maintains a scientific and measured tone, highlighting the importance of further rigorous investigation to understand and optimize these therapies for diverse chronic conditions fully