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The clinical investigators specifically noted that "gastrointestinal adverse events were partially mitigated by the use of a lower starting dose." Starting at 1 mg, which is what the Phase 3 TRIUMPH trials use, provides even more tolerability protection

The short half-life of glucagon-like peptide-1 in plasma does not reflect its long-lasting beneficial effects

Taking GLP-1s appears to alter these areas and change the levels of reward-related neurotransmitters dopamine and glutamate, a review of related studies suggests

That does not mean every case of dementia is preventable

I would still want to prevent those from occurring