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Cyanocobalamin is the synthetic form of B12 used in most Lipo C formulations it requires conversion to methylcobalamin in the liver before it becomes biologically active, and it triggers histamine release in 812% of users, producing flushing or warmth

Fitzgerald et al., 2017

Hence, individualized treatment strategies, considering factors such as patient age, underlying comorbidities, and DPN severity, will be critical for optimizing therapeutic outcomes

From there, vasodilation is promoted and new blood vessel formation takes place in the injured tissue

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