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Animal experiments have shown that administration of LPS to germ-free mice induces microglial activation and increases pain sensitivity (52)

In another randomized, double-blind, placebo-controlled clinical trial, 32 patients with colorectal cancer and gastric cancer were randomly given NAC (two 600 mg tablets) or placebo tablets, and NAC was found to reduce the incidence of oxaliplatin-induced neuropathy and delay its occurrence after oxaliplatin chemotherapy [69]

After being diagnosed, primary breast tumors are surgically resected and those patients with estrogen receptor- (ER)-positive tumors are typically prescribed tamoxifen as an adjuvant treatment 2,3,4

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The mucolytic, antitussive effect of NAC has long been known in the health circles because of its ability to break down disulfide bridges in mucus and secretions