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Self-directed combination therapy is strongly discouraged due to safety concerns

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This shouldnt deter people from trying the medicine if it is indicated (obesity or type 2 diabetes), as it is not very common and can be managed with dose changes plus or minus anti-depressant medication, lead report author Spencer Nadolsky, an obesity medicine specialist and CEO of the virtual health clinic Vineyard, told Gizmodo

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Very dry skin types : You may need a richer cleanser option, or youll need to be especially diligent about moisturizing afterward