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One possible scenario is the metabolic cofactor NADPH, which is known to be required not only for lipid synthesis but also for the function of antioxidant reductases, such as glutathione reductase (GSR) and thioredoxin reductase (TXNRD) 86
Conclusions Numerous medicinal plants and their bioactive compounds exhibit significant potential in preventing drug-induced ototoxicity through a variety of mechanisms, primarily by addressing oxidative stress and inflammation
