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These observations suggest that introducing the leucine plug has increased the force threshold necessary to induce ligand-induced cleavage and activation

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Market analysts anticipate eight or more novel GLP-1-based approvals for chronic weight management over the next four years, as the drug class extends from its metabolic origins into a broader platform for addressing diseases with underlying inflammatory and cardiometabolic components

Similar patterns of FTH1 upregulation and TfR1 downregulation have also been reported in primary murine chondrocytes under iron overload (93) and in cartilage tissue from OA models (94)

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