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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

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Ocular / Retinal Models Epithalon has also been tested in visual system research: In rodent models of retinal degeneration, Epithalon has been associated with preservation of retinal structure and improvement in electrophysiologic measures of retinal function in a subset of treated subjects