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When to Contact Your Prescriber Self-injection technique issues that warrant a clinical call include: a lump or hardened area at the injection site that persists for more than 2 weeks (possible lipohypertrophy), signs of infection (expanding redness, warmth, pus, or fever), allergic reaction at the site (hives, intense itching, or swelling beyond 2 inches), and any systemic symptoms such as severe abdominal pain, persistent vomiting, or signs of pancreatitis

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Effect of liraglutide on cardiovascular events in patients with type 2 diabetes mellitus and polyvascular disease: results of the LEADER Trial