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Meanwhile, to further enhance the convenience of wound therapy and achieve controlled drug release, hydrogel-based (e.g., hyaluronic acid, alginate, and gelatin) delivery systems for drugs or exosomes can be established, providing an integrated intervention-delivery solution for precise regulation of ferroptosis in diabetic wounds [49, 87, 89, 98, 108]

Specific application sequences Sequence 1: Peptides first, then retinol (same routine) Cleanse face Apply peptide serum to damp skin Wait 1-2 minutes for absorption Apply retinol Wait 1-2 minutes Apply moisturizer Best for: Most peptides (Matrixyl, Syn-Coll, general collagen peptides) Sequence 2: Retinol first, then peptides (less common) This is rarely recommended because retinol benefits from being closer to skin, and peptides are often in hydrating serums that work well after retinol

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