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TXNs are considered members of the thioredoxin family of proteins based on the comparative sequence analysis, presence of common motif WCPPC of the oxidoreductase superfamily in their catalytic center and some other features that are conserved throughout this type of oxidoreductases

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Despite its low potency at both receptors and less-certain in vivo activity at the GcgR, chronic OXM treatment decreased body weight and food intake in rodents when GLP-1R action was present [79,80,81]