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The MariTide Phase 2 data presented in November 2024 were highly significant: MariTide demonstrated robust weight loss at 52 weeks with no plateau meaning continued weight loss trajectory at the end of the study period, unlike semaglutide and tirzepatide which show plateau effects and significant improvements in cardiometabolic parameters

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Older oral anti-obesity agents phentermine-topiramate extended release, naltrexone-bupropion, orlistat have smaller mean effects but are often available at far lower cost, sometimes as generics