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At least three possible mechanisms could explain the increased lactate levels seen in FM: problems with anaerobic energy production/mitochondrial dysfunction, neuroinflammation and oxidative stress

Membranes were pre-incubated with PF 06882961 or OWL-833 for 10 min prior to assessment of BRET signal between Nluc-hGLP-1R and AF568-GLP-1 This was assessed using a PHERAstar (BMG LabTech) at 10 sec intervals (25 C)

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