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The Journal of Pharmacology and Experimental Therapeutics, 329(3), 11101116

Sa and Das, 2008

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105, 106, 107, 108, 109, 110, 111 Osteosarcomatous metaplasia in a malignant melanoma may be the sequela of an alteration in benign stromal fibroblasts as a host response to the tumor, or it could represent a divergent differentiation pattern, whereby melanoma cells acquire the machinery necessary for the production of malignant osteoid

The APOE-TR model is a mouse knock-in model where exons 24 (comprising the mouse APOE gene) are replaced with human APOE in 129xC57BL/6 mice back-crossed to C57BL/6 mice (Sullivan et al., 1997)