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The Bcl-2 family, in contrast, includes Bcl-2, which can protect cells from various apoptotic triggers, and Bax, an apoptosis agonist that acts through heterodimerisation with Bcl-2 [43]
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Others see modest results, hit plateaus, regain weight when they stop the drug, or cant tolerate the side effects
The average BMI of patients decreased from 43.1 to 41.5, and their mean weight dropped significantly from 117.7kg to 111.6kg, with one-third of patients losing 10kg or more during the treatment period
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