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The AMPK pathway is activated by the PI3K/AKT pathway, which promotes the translocation of the glucose transporter 4 (GLUT4) from intracellular vesicles to the plasma membrane

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In conclusion, PCs improve diabetes-induced cardiovascular diseases through various mechanisms, particularly by regulating endothelial function, reducing oxidative stress, inhibiting inflammation, and modulating vascular smooth muscle cell proliferation, exhibiting significant neuroprotective and cardiovascular protective effects

This research was funded by Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES)Finance Code 001