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The study also revealed an unexpected pathway-dependent response: in telomerase-positive cancer cell lines, telomere elongation occurred through alternative lengthening of telomeres (ALT) activation rather than telomerase upregulation, suggesting that the AEDG sequences interaction with telomere maintenance pathways is more complex than initially characterized

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DOI Park JR, Lee H, Kim SI, Yang SR

Neuroinflammation and neurodegeneration in human brain at single-cell resolution