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NNMT is an enzyme that converts nicotinamide to N-methylnicotinamide, consuming methyl groups and potentially reducing NAD+ availability

Comment: A few commenters stated that hospitals caring for a significant proportion of high-acuity and complex patients (such as teaching hospitals and VHA hospitals) could be disproportionately affected by higher numbers of adverse events captured in the Safety of Care measures, even if overall quality is high

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Impacts of the Updated Wage Indexes We estimate that our update of the wage indexes based on the fiscal year (FY) 2026 IPPS final rule wage indexes will result in a 0.1 percent increase for urban hospitals under the OPPS and a 0.2 percent increase for rural hospitals