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PubMed ID: 11673763 Mor MI et al

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Interestingly, the up-regulation of M2 markers demonstrates that Ex-4 promotes the polarization toward the anti-inflammatory M2 phenotype post MCAO in both aged T2DM/obese and normal mice, implying a new mechanism based on Ex-4- mediated neuroprotective efficacy (135)

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These changes likely result from the combination of weight loss, improved blood sugar control, and the medications direct effects on metabolic processes