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The relevance here is evidential, not procedural: because delivery and stability vary so much, comparing results across products and studies is genuinely difficult, and that heterogeneity is one reason a clean answer to the title question has been so slow to emerge

Log dose, length, and what other supplements or medications you are taking, so you can pinpoint interactions

Heales SJ, Lam AA, Duncan AJ, Land JM

Niacinamide: A type of vitamin B3 that minimizes enlarged pores, tightens pores, improves uneven skin tone, softens fine lines & wrinkles, diminishes dullness and strengthens a weakened surface

Rota L, Pellegrini C, Benvenuti L, Antonioli L, Fornai M, Blandizzi C, et al