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210 The principles of Mendelian randomization, which leverages genetic variants influencing exposures (e.g., UA levels), can serve as a natural randomization method to study the causal effects of these exposures on disease outcomes

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1), which is further supported by unaltered mRNA levels of inflammatory genes TNF, IL-6 and IL-1 (supplementary Fig

As I said before PA is still thought to be the primary culprit here, other causes of B12 deficiency such as malabsorption caused by metformin, H2 blockers, PPIs, parasites, etc