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For people with prediabetes or insulin resistance who do not yet meet diagnostic criteria for type 2 diabetes, tirzepatide can normalize glucose metabolism before the disease progresses

This is when three-site rotation becomes most important

Any data exclusions are described in their respective section

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Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression